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gdc 0077  (MedChemExpress)


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    MedChemExpress gdc 0077
    Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib <t>(GDC-0077).</t> All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.
    Gdc 0077, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gdc+0077/Inavolisib/pmc13092703-52-0-5
    Average 94 stars, based on 6 article reviews
    gdc 0077 - by Bioz Stars, 2026-10
    94/100 stars

    Images

    1) Product Images from "PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy"

    Article Title: PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

    Journal: Neoplasia (New York, N.Y.)

    doi: 10.1016/j.neo.2026.101305

    Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.
    Figure Legend Snippet: Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Techniques Used: Inhibition, Control, Comparison

    Related Articles

    Concentration Assay:

    Article Title: A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy
    Article Snippet: BYL-719, a potent and selective PI3Kα ( PIK3CA/ p110) inhibitor with IC of 5nM, was purchased from MCE (Cat# HY-15244, MedChem Express). .. GDC-0077 and AZD-5363 were also purchased from MedChem Express, All drugs were dissolved in DMSO, stored at -80EC, and diluted with an appropriate concentration before use according to the manufacturer’s protocol. .. TCGA (The Cancer Genome Atlas) data sets, including 297 cervical cancers (CESC), AACR-GENIE (AACR Project Genomics Evidence Neoplasia Information Exchange), including 190 CC, were accessed through the cBioPortal for Cancer Genomics analytic tool [ ] ; A dataset of 22 CC cell lines.

    other:

    Article Title: D‐1553: A novel KRAS G12C inhibitor with potent and selective cellular and in vivo antitumor activity
    Article Snippet: Carboplatin, cisplatin, oxaliplatin, and GDC‐0077 were purchased from MCE.



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    Image Search Results


    Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Journal: Neoplasia (New York, N.Y.)

    Article Title: PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

    doi: 10.1016/j.neo.2026.101305

    Figure Lengend Snippet: Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Article Snippet: GDC-0077 was also purchased from MedChem Express (Cat# HY-101562.

    Techniques: Inhibition, Control, Comparison

    Journal: Cell Reports Medicine

    Article Title: A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

    doi: 10.1016/j.xcrm.2025.102029

    Figure Lengend Snippet:

    Article Snippet: GDC-0077 , Selleckchem , S8668.

    Techniques: Transduction, Recombinant, Saline, Software, Sterility, Transferring, Ointment